Abstract: In the post-poverty-alleviation era, the lack of health information among middle-aged and senior citizens in minority villages have become an urgent social issue. It has become a common phenomenon for youths to search online health information for their parents due to their higher level of media literacy in these villages. This study viewed the university students from minority villages in southwest China as research objects to clarify the underlying mechanism of active online search of health information of youths and their intensions in ethnic minority villages. The results showed that the youths’ anxiety about their parents’ health affected their perceived need of health information, while first-hand experience affected the perceived usefulness of such information. Also, both perceived need and perceived usefulness drive the behaviors of online search. The elderly’s trust only moderated the relationship between first-hand experience and information usefulness. Promoting media literacy of university students, therefore, is important to encourage them to actively search online health information for their parents, and hence address the health information issue of middle-aged and older people in minority villages.