Abstract: The palm leaf manuscript is an important human cultural heritage with much value in history, religion, culture and science. Due to its materials, preservation environment, and so forth, the palm leaf manuscript is in a state of severe endangerment. Digitizing and constructing the database of palm leaf manuscripts have a positive significance for protecting and inheriting their value. Considering the characteristics of palm leaf manuscripts, and lessons from foreign theoretical and practical research on the database of palm leaf manuscripts, the paper discusses the construction of characteristic database of palm leaf manuscripts in China, in terms of resource selection, information collection, data processing, and retrieval. It highlights the characteristics of such database, such as the three-dimensional rendering as well as the full-text retrieval in multiple languages.