Abstract: Since the outbreak of COVID-19, biosafety and biosecurity has drawn high attention from countries around the world. Biosafety and biosecurity governance has become increasingly important. The prevention and resolution of biosafety and biosecurity risks require the protection of biosafety and biosecurity intelligence, and the construction of biosafety and biosecurity governance system cannot do
without the support of such intelligence work. Therefore, it is of great significance to carry out research on biosafety and biosecurity intelligent support system for biosafety and biosecurity governance. First of all, the important connotation of biosafety and biosecurity intelligence should be clarified for the governance. Secondly, according to the current situation of biosafety and biosecurity governance, the intelligence support system oriented to the governance was constructed, and the “three major systems” in the intelligence support system were analyzed in depth. On the basis, the operational guarantee of biosafety and biosecurity intelligence support system was described. Finally, the biosafety and biosecurity intelligence support system for biosafety and biosecurity governance was demonstrated by taking COVID-19 epidemic as an example. The research showed that the biosafety and biosecurity intelligence support system can be a key support for preventing and resolving biosafety and biosecurity risk, which is conducive to improving the ability of biosafety and biosecurity governance, and then promoting the modernization of national biosafety and biosecurity governance.