Abstract: The Protocol for Exchanging Serial Content (PESC) issued by the American National Standards Institute (NISO) can help the publishers, publisher agents, and discovery service organizers to solve some problems such as inconsistent formats, difficult exchanges, lack of content, and inefficiency in the process of mass transfer and exchange between different organizations. In this paper, the background of PESC, the specification of its content package’s format structure, the consistency of different levels of PESC, the effective implementation guide of PESC, and the lessons for China’s industry standards are elaborated in detail to advance the library community in China. The understanding of the PESC protocol enhances the possibility of low-cost and efficient content exchange between parties in the continuous publishing process. At the same time, it also has important reference value for the establishment and implementation of a standardized and unified exchange protocol standard for continuous publishing content in China’s library community