Abstract: In the newly discovered centennial old Guihai Nian Gengliubu, the Southeast Asia routes, especially Siam Bay route, are highly consistent with Zheng He’s voyages. Because Zheng He’s nautical chart did not leave the provisions of zhenlu in Siam Bay, it is difficult to verify the place names. Some scholars’ textual research reached the conclusions that the important islands and reefs such as Daheng, Xiaoheng, Bijia, Guishan in the Siam Bay are very different from those in the New Version of Zheng He’s Nautical Atlas. After conducting a digital humanistic textual research on the related zhenlu, it was found that there were unreasonable textual research conclusions in both of them. The author puts forward the corrective opinions on important misinterpretation of the relevant documents, and proposes comprehensive digital humanistic research suggestions on the sea road and compass course of all Chinese dynasties represented by Zheng He’s Nautical Chart.