Abstract: Public government trust is critically important under major public health emergencies. This paper analyzes the mechanism of information communication factors on government trust, and enriches the existing research theories. Using the COVID-2019 survey jointly launched by the Shanghai Government Development Research Center and Peng Pai Research Institute, based on the 146 081 sample data and OLS regression method, this paper empirically analyzes the impact of public information concern, media trust and public government information disclosure satisfaction on government trust. The results show that public information concern about COVID-2019 has a negative impact on government trust, and the central government media trust, local government media trust and public information disclosure satisfaction have a positive moderation effect on public information concern and government trust, while social media trust has no significant moderation effect. From the perspective of information dissemination, this paper puts forward serveral policy recommendations to enhance government trust.